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  • The effect of urgent-start peritoneal dialysis and urgent-start hemodialysis on clinical outcomes in patients with chronic kidney disease: an updated systematic review and meta-analysis

    Recently, urgent-start peritoneal dialysis (PD) has been suggested in place of urgent-start hemodialysis (HD) in cases of chronic kidney disease (CKD). However, the comparative effectiveness of these methods is still unclear. This study compared the outcomes of urgent-start PD and urgent-start HD in CKD patients.

    Read the abstract » | (added 2024-03-15)

    Tags: Dialysis related Complications, Hemodialysis, Kidney Disease, Mechanical Complications, Mortality, Peritoneal Dialysis, Renal Replacement Therapy

  • Impact of Prior Abdominal Procedures on Peritoneal Dialysis Catheter Outcomes: Findings From the North American Peritoneal Dialysis Catheter Registry

    A history of prior abdominal procedures may influence the likelihood of referral for peritoneal dialysis (PD) catheter insertion. To guide clinical decision making in this population, this study examined the association between prior abdominal procedures and outcomes in patients undergoing PD catheter insertion.

    Read the abstract » | (added 2024-03-15)

    Tags: Dialysis, PD, PD Catheter Outcomes, End Stage Kidney Disease, Peritoneal Dialysis, Prior Abdominal Surgery

  • Non-mechanical Complications of PD

    Learn from a review of non-mechanical PD complications, including oddly-colored PD effluent, encapsulating peritoneal sclerosis, and metabolic changes.

    Read the abstract » | (added 2024-01-17)

    Tags: Non mechanical PD Complications, Oddly colored PD Effluent, Encapsulating Peritoneal Sclerosis, Metabolic Changes

  • How Sugar Harms the Peritoneum and Causes Fibrosis

    HOW does sugar harm the peritoneum? An RNA sequencing study looked at peritoneal endothelial cell (EC) function in mice and human ESRD cells in the presence or absence of glucose. In mice, glucose increased EC proliferation, permeability, and inflammation. Blocking glucose caused a therapeutic benefit. Human cells reacted in a similar way.

    Read the abstract » | (added 2023-12-15)

    Tags: Sugar, Glucose, Peritoneum, RNA Sequencing, Endothelial Cell Function

  • Melatonin Shows Promise for Preventing Peritoneal Fibrosis

    Glucose in peritoneal dialysate drives inflammation and angiogenesis, which lead to fibrosis that can cause loss of use of the membrane. A new study from China proposes that melatonin may break this cycle.

    Read the abstract » | (added 2023-10-13)

    Tags: Melatonin, Peritoneal Fibrosis, Glucose, GSDME, Pyroptosis

  • Magnesium Inhibits the Peritoneal Calcification of Late-stage EPS in Mice

    Encapsulating peritoneal sclerosis (EPS) is a devastating and potentially lethal complication of PD. The reasons for EPS are not clear, but phosphate loading seems to contribute to the condition. This study successfully induced peritoneal calcification in mice—and found that administering magnesium into the peritoneum suppressed fibrosis and calcification.

    Read the abstract » | (added 2023-10-13)

    Tags: Encapsulating Peritoneal Sclerosis, Magnesium, Peritoneal Calcification, EPS

  • Intraperitoneal Pressure and Hernias

    While it has long been believed that high intraperitoneal pressure (IPP) is a factor in hernia development, this notion had not been proven. A prospective observational study of 124 incident PD patients over a 10-year period suggests that the common wisdom was correct. Higher IPP at PD onset, older age, higher BMI, prior hernia, laparoscopic PD catheter placement, and technique failure were related to hernia formation.

    Read the abstract » | (added 2023-09-13)

    Tags: Intraperitoneal Pressure, IPP, Hernia, Incident PD, Hernia Formation Factors

  • Systematic Review of Culture-directed Antibiotics for Peritonitis

    A review of 28 articles identified 18 antibiotics used for peritonitis, of which 9 (cefotaxime, ceftriaxone, daptomycin, ofloxacin, and teicoplanin in glucose-based solutions, tobramycin in Extraneal solution only and fosfomycin in Extraneal, Nutrineal, Physioneal 1.36% and 2.27% glucose solutions ) can be dosed interaperitoneally. Stability has not yet been demonstrated for all of these.

    Read the abstract » | (added 2023-08-16)

    Tags: Peritonitis, Antibiotics, Culture directed Antibiotics, Peritoneal Dialysis Solutions

  • 2023 AJKD Core Curriculum in Nephrology

    Acute PD, more use of home treatments, and better peritoneal solute transfer models are part of the content of the new Core, which emphasizes the latest data for prevention and management of infectious and noninfectious complications of PD.

    Read the abstract » | (added 2023-08-16)

    Tags: Acute PD, Core Curriculum, Complications Of PD, Home Dialysis

  • How Glucose Causes Peritoneal Fibrosis

    Constant glucose exposure from PD dialysate often causes fibrosis that can make further PD impossible. High glucose causes chronic inflammation, interferes with lipid metabolism, and leads to angiogenesis and fibrosis. RAAS activation contributes to this process as well. There may be benefit to looking at the upstream pathways to see if there are ways to block fibrosis.

    Read the abstract » | (added 2023-08-16)

    Tags: High Glucose, PD Dialysate, Fibrosis