Journal Watch

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  • HOW do AGE’s Cause Peritoneal Fibrosis?

    For years, researchers have known that the advanced glycation endpoints (AGEs) that form when sugar-based PD fluid is made harm the membrane. But, we didn’t know why. Human cell modeling finds that AGEs cause outer layer peritoneal cells (epithelial) to become connective tissue cells (mesenchymal).

    Read the abstract » | (added 2019-03-12)

    Tags: AGEs, Mesothelial, Epithelial, STAT3

  • Urgent-start PD Catheter Placement - Surgical vs. Percutaneous

    PD catheter placement does NOT have to be limited to just minimally-invasive percutaneous procedures, suggests a literature review. But, minimizing intraperitoneal pressure for the first 2 weeks IS important.

    Read the abstract » | (added 2019-02-14)

    Tags: PD, Catheter, Urgent start, Complications

  • Protein Clearance Predicts Mortality on PD

    Protein clearance on PD may be a marker of peritoneal inflammation. Among 711 PD patients followed for at least one year, each 10mL/day rise in protein clearance was linked with a 10.4% increase in the risk of all-cause mortality (p=0.008). Protein clearance was linked with serum albumin and C-reactive protein levels.

    Read the abstract » | (added 2018-12-14)

    Tags: Protein Clearance, Peritoneal Dialysis, Mortality

  • New Ideas for Incremental PD

    Starting incremental PD without the exclusive focus on residual plus peritoneal clearances may ease transitions of new patients onto dialysis—and reduce our “obsession” with small moleule kinetics.

    Read the abstract » | (added 2018-06-12)

    Tags: Incremental PD, Peritoneal Dialysis

  • High Peritoneal Transport and Long-term PD Outcomes

    Among 470 patients who did PD for up to 10 years in Hong Kong, the peritoneal transport rate was able to differentiate survivors. After the first few years of PD, having high peritoneal transport became a significant risk factor for mortality.

    Read the abstract » | (added 2018-05-11)

    Tags: Trend Of Peritoneal Transport, Patient Survival

  • A New, Early Marker for Encapsulating Peritoneal Sclerosis?

    Can a drop in dialysate sodium sieving during a PET forecast EPS in advance? A 20-year, controlled longitudinal cohort study found a correlation. Of 161 incident PD patients, 13 went on to develop EPS—and sodium was the best predictor.

    Read the abstract » | (added 2018-02-15)

    Tags: Dialysate Sodium Sieving, PET, EPS

  • Peritoneal Membrane Transport and Survival on PD

    Among 470 PD patients followed for up to 10 years, high transporters were stable for the first few years, and after 5 years or so, PD adequacy began to slowly fall. The rate of PD transport did not affect patient survival.

    Read the abstract » | (added 2018-01-11)

    Tags: High Transporters, PD Adequacy, PD Transport, Patient Survival

  • Olive Oil Polyphenols and Peritoneal Fibrosis

    It’s not just for cooking any more. Researchers have studied the ability of components of extra virgin olive oil to prevent or treat fibrosis and thickening of the peritoneal membrane, both in vivo and in vitro. The polyphenols were not able to reverse fibrosis, but did help to prevent it, and the authors suggest further research.

    Read the abstract » | (added 2017-12-14)

    Tags: Extra Virgin Olive Oil, Fibrosis, Peritoneal Membrane, Polyphenols

  • Risk Factors for Encapsulating Peritoneal Sclerosis

    EPS is a rare but devastating complication of PD. Among a series of 703 PD patients in Japan between 1980 and 2015, 6.3% developed EPS. Identified risk factors included a history of longer-duration peritonitis and longer time on PD, while use of biocompatible PD fluid reduced the risk. Read the abstract.

    Read the abstract » | (added 2017-11-13)

    Tags: Biocompatible Peritoneal Dialysis Fluid, Dialysate To Plasma Creatinine (D/P Cr) Ratio By Peritoneal Equilibration (PET), Peritoneal Dialysis, Peritoneal Dialysis Duration, Peritonitis

  • Urgent-start PD in Brazil

    In a prospective study, 51 patients who needed dialysis urgently began peritoneal dialysis instead of hemodialysis. Even with high-volume dialysate used less than 72 hours after catheter placement (on alternate days in the dialysis clinic), the option was feasible and safe. Read the abstract.

    Read the abstract » | (added 2017-11-13)

    Tags: Acute Peritoneal Dialysis, Unplanned Peritoneal Dialysis, Urgent start Dialysis, Urgent start Peritoneal Dialysis