Journal Watch

  • PD Probiotics, Malnutrition, and Health-related Quality of Life

    In a controlled trial that randomized 116 PD patients into a probiotic and a control group, 2 months of probiotics reduced inflammation markers (HS-CRP and IL-6), and significantly improved serum albumin, upper arm circumference, and triceps skinfold thickness. The probiotic group also had higher physical and social functioning scores.

    Read the abstract » | (added 2020-07-10)

  • Soy Isoflavones Reduce Heart Disease Risk Factors in PD

    A trial randomly assigned 40 PD patients to a soy isoflavone or placebo group, and took several measures of inflammation at baseline and 8 weeks. At the end of the study, those in the soy group had significant decreases in serum VCAM-1 and serum ICAM-1, two cardiovascular disease risk factors in PD patients

    Read the abstract » | (added 2020-06-10)

  • 10-year PD Survival

    In a group of 533 incident PD patients (mean starting age of 48 +16 years) followed from 2006 until 2018, survival at 1 year was 93%, at 3 years 81%, at 5 years 64%, and at 10 years 36%. Encapsulating peritoneal sclerosis (EPS) occurred in 1.3%.

    Read the abstract » | (added 2020-06-10)

  • Safety of Bedside PD Catheter Placement During COVID-19

    Urgent-start PD is being used to address acute kidney injury due to COVID-19. A New York hospital successfully placed 14 PD catheters bedside to minimize use of critical hospital resources. The catheter did not work in one patient, who required HD. Another had bleeding stopped with compression and withholding of anticoagulants. The remaining 12 worked at follow up (3-18 days), with long-term follow-up suggested.

    Read the abstract » | (added 2020-06-10)

  • Blood Vessel Damage Key to Encapsulating Peritoneal Sclerosis (EPS)

    A study evaluated tissue samples from 174 PD patients with EDS and had used either conventional or neutral pH, low glucose degradation product PD solution. The conventional PD solution group had less angiogenesis but more severe blood vessel damage (P <0.001) and a higher rate of EPS relapse. Blood vessel damage was milder in the neutral pH group.

    Read the abstract » | (added 2020-06-10)

  • Does Extended Hour HD Helps Survival After Returning to Standard HD?

    In an analysis of data from the ACTIVE Dialysis Trial, 200 standard HD patients were randomly assigned to 12 or 24 hours of treatment per week for a year, with follow up at 24, 36, and 60 months after a return to 12 hours of treatment per week. Long-term survival was not improved.

    Read the abstract » | (added 2020-06-10)

  • How to Prevent and Manage COVID-19 in PD Patients

    A comprehensive set of recommendations from China suggest reinforcing hygiene education, avoiding fear, and encourage patients to stay home—deferring clinic visits or using virtual ones when possible.  When clinic or hospital visits are necessary, safety steps are described in detail.  Covid-19 positive patients must be quarantined.  Download the article

    Read the abstract » | (added 2020-05-12)

  • Physical Activity and Survival in PD

    Among 79 PD patients, fat and muscle mass, strength, and physical performance were not different between patients who were alive 2 years later and those who were not. However, the odds of death were 7.4 times higher in those whose level of physical activity was below the group’s median.

    Read the abstract » | (added 2020-05-12)

  • Universal AVF Back-up for PD Patients Reduces HD Catheter Use

    Should an arteriovenous fistula always be placed as a PD back-up for new patients? A retrospective study of two hospitals examined this question. Hospital RAH (n=142) did universal AVF back-up at PD start. Hospital PAH (n=232) did selective AVF back-up for “high risk” patients only. Yet, the transfer-to-HD rate at RAH was about half that of RAH (23% vs. 43%)—as was the HD catheter usage rate (33% vs. 65%; p<0.001), despite a population at RAH that was more likely to be older, Caucasian, and have diabetes.

    Read the abstract » | (added 2020-05-12)

  • PD Catheter Placement Outcomes: Urgent- vs. Elective-start

    After analyzing 13 years of data comparing urgent-start (n=29) and elective-start (n=211) PD, the only significant difference between the mostly-comparable groups was a higher incidence of catheter leaks. Complication and catheter removal rates at 3 and 12 months were similar, as were days to first complication and 12-month patient survival. Catheter placement technique did not affect the outcomes.

    Read the abstract » | (added 2020-05-12)