Journal Watch - Peritoneal
Some PD PETs Are Better Than Others
There are three ways to do a peritoneal equilibrium test (PET) to measure how well someone’s peritoneum is able to transport water and wastes. Compared to a traditional PET, a modified PET had good agreement in 21 patients—but the so-called mini-PET did not.
Read the abstract » | (added 08/14/2019)
Will Zinc Supplements One Day Help Prevent Peritoneal Sclerosis?
Ironically, PD saves lives, but high-glucose PD fluid damages the peritoneum, leading to fibrosis that can make PD impossible. By activating a complex metabolic pathway, a study in rats found that supplementing with zinc helped prevent fibrosis.
Read the abstract » | (added 06/13/2019)
HOW do AGE’s Cause Peritoneal Fibrosis?
For years, researchers have known that the advanced glycation endpoints (AGEs) that form when sugar-based PD fluid is made harm the membrane. But, we didn’t know why. Human cell modeling finds that AGEs cause outer layer peritoneal cells (epithelial) to become connective tissue cells (mesenchymal).
Read the abstract » | (added 03/12/2019)
Urgent-start PD Catheter Placement - Surgical vs. Percutaneous
PD catheter placement does NOT have to be limited to just minimally-invasive percutaneous procedures, suggests a literature review. But, minimizing intraperitoneal pressure for the first 2 weeks IS important.
Read the abstract » | (added 02/14/2019)
Protein Clearance Predicts Mortality on PD
Protein clearance on PD may be a marker of peritoneal inflammation. Among 711 PD patients followed for at least one year, each 10mL/day rise in protein clearance was linked with a 10.4% increase in the risk of all-cause mortality (p=0.008). Protein clearance was linked with serum albumin and C-reactive protein levels.
Read the abstract » | (added 12/14/2018)
New Ideas for Incremental PD
Starting incremental PD without the exclusive focus on residual plus peritoneal clearances may ease transitions of new patients onto dialysis—and reduce our “obsession” with small moleule kinetics.
Read the abstract » | (added 06/12/2018)
High Peritoneal Transport and Long-term PD Outcomes
Among 470 patients who did PD for up to 10 years in Hong Kong, the peritoneal transport rate was able to differentiate survivors. After the first few years of PD, having high peritoneal transport became a significant risk factor for mortality.
Read the abstract » | (added 05/11/2018)
A New, Early Marker for Encapsulating Peritoneal Sclerosis?
Can a drop in dialysate sodium sieving during a PET forecast EPS in advance? A 20-year, controlled longitudinal cohort study found a correlation. Of 161 incident PD patients, 13 went on to develop EPS—and sodium was the best predictor.
Read the abstract » | (added 02/15/2018)
Peritoneal Membrane Transport and Survival on PD
Among 470 PD patients followed for up to 10 years, high transporters were stable for the first few years, and after 5 years or so, PD adequacy began to slowly fall. The rate of PD transport did not affect patient survival.
Read the abstract » | (added 01/11/2018)
Olive Oil Polyphenols and Peritoneal Fibrosis
It’s not just for cooking any more. Researchers have studied the ability of components of extra virgin olive oil to prevent or treat fibrosis and thickening of the peritoneal membrane, both in vivo and in vitro. The polyphenols were not able to reverse fibrosis, but did help to prevent it, and the authors suggest further research.
Read the abstract » | (added 12/14/2017)