Journal Watch - PD Fluid
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Replacing Dextrose in PD Fluid—with Steviol Glycosides?
Using glucose to remove water will scar the peritoneum over time—making PD a short-term option for most. Icodextrin (Extraneal®) is a glucose-free alternative. Now, researchers are looking at another one: steviol glycosides (SG), the compounds that make stevia taste sweet. Using artificial membranes and mice, dialysate with 1.5%, 1%, and even 0.75% SG had similar results as glucose-based fluids—with better biocompatibility.
Read the abstract » | (added 2022-09-13)
Tags: Dextrose, PD Fluid, Steviol Glycosides, Icodextrin
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Biocompatible PD Fluids: A Systematic Review
Are neutral pH, low glucose degradation product (GDP), and icodextrin PD fluids better than standard ones? A Cochrane review of 42 studies (n=3,262 ) found that neutral pH and low GDP fluids significantly improved residual kidney function (RKF) vs. standard fluids—and more so over time, and urine volume was better preserved. Icodextrin boosted ultrafiltration without reducing RKF.
Read the abstract » | (added 2018-11-11)
Tags: Biocompatible, PD Fluid