Progress in PD Fluid

While glucose-based PD fluids are inexpensive, non-physiological PD fluid can, ironically, damage the peritoneum and cause devastating complications including peritoneal fibrosis and encapsulating peritoneal sclerosis (EPS). Neutral pH and solutions low in glucose degredation products (GDPs) help preserve peritoneal integrity and residual renal function, while using other osmotic agents such as icodextrin can improve ultrafiltration. Alternative buffers are also helpful.

Read the abstract » | (added 2025-03-13)

Tags: PD Fluid, Glucose Degredation Products, Icodextrin, Peritoneal Fibrosis, Encapsulating Peritoneal Sclerosis

Do Ketoanalogue (KA) Supplements Preserve Residual Kidney Function in PD?

A 1-year, six center, randomized, double-blind trial investigated the impact of KA supplements on RKF in 153 CAPD patients vs. placebo. For patients with early PD initiation, the KA group had a significantly lower decline in RKF. No differences were found in RKF decline in those with late PD starts or in PD adequacy, peritoneal function, nutritional status, or quality of life scores between groups.

Read the abstract » | (added 2024-12-11)

Tags: KA Supplements, Residual Kidney Function, CAPD, Ketoanalogues

Best Practices in Interventional Radiology for Peritoneal Dialysis

The Italian Society of Nephrology has endorsed a practical core curriculum for interventional nephrology in PD and has made it available on the Society website. The core curriculum addresses abdominal wall hernias, catheter placement with open surgical technique, video laparoscopy, cuff-shaving and more.

Read the abstract » | (added 2024-08-16)

Tags: Peritoneal Dialysis, Interventional Nephrology, Catheter Placement, Hernia

Risk Factors for Cognitive Impairment in Peritoneal Dialysis

A retrospective analysis of 268 CAPD patients from January 2020 to September 2023. categorized participants into a cognitively impaired (CI; 58.2%) and a cognitively normal (CN) group. Logistic regression analysis identified male gender, older age, lower educational attainment, hypercholesterolemia, and elevated high-sensitivity C-reactive protein levels as independent risk factors for CI in CAPD patients (P < .05), while dialysis duration and residual renal function were protective against CI (P < .05).

Read the abstract » | (added 2024-08-16)

Tags: CAPD, Cognitive Impairment, Logistic Regression Analysis, Risk Factors

Impact of Prior Abdominal Procedures on Peritoneal Dialysis Catheter Outcomes: Findings From the North American Peritoneal Dialysis Catheter Registry

A history of prior abdominal procedures may influence the likelihood of referral for peritoneal dialysis (PD) catheter insertion. To guide clinical decision making in this population, this study examined the association between prior abdominal procedures and outcomes in patients undergoing PD catheter insertion.

Read the abstract » | (added 2024-03-15)

Tags: Dialysis, PD, PD Catheter Outcomes, End Stage Kidney Disease, Peritoneal Dialysis, Prior Abdominal Surgery

The effect of urgent-start peritoneal dialysis and urgent-start hemodialysis on clinical outcomes in patients with chronic kidney disease: an updated systematic review and meta-analysis

Recently, urgent-start peritoneal dialysis (PD) has been suggested in place of urgent-start hemodialysis (HD) in cases of chronic kidney disease (CKD). However, the comparative effectiveness of these methods is still unclear. This study compared the outcomes of urgent-start PD and urgent-start HD in CKD patients.

Read the abstract » | (added 2024-03-15)

Tags: Dialysis related Complications, Hemodialysis, Kidney Disease, Mechanical Complications, Mortality, Peritoneal Dialysis, Renal Replacement Therapy

Non-mechanical Complications of PD

Learn from a review of non-mechanical PD complications, including oddly-colored PD effluent, encapsulating peritoneal sclerosis, and metabolic changes.

Read the abstract » | (added 2024-01-17)

Tags: Non mechanical PD Complications, Oddly colored PD Effluent, Encapsulating Peritoneal Sclerosis, Metabolic Changes

How Sugar Harms the Peritoneum and Causes Fibrosis

HOW does sugar harm the peritoneum? An RNA sequencing study looked at peritoneal endothelial cell (EC) function in mice and human ESRD cells in the presence or absence of glucose. In mice, glucose increased EC proliferation, permeability, and inflammation. Blocking glucose caused a therapeutic benefit. Human cells reacted in a similar way.

Read the abstract » | (added 2023-12-15)

Tags: Sugar, Glucose, Peritoneum, RNA Sequencing, Endothelial Cell Function

Melatonin Shows Promise for Preventing Peritoneal Fibrosis

Glucose in peritoneal dialysate drives inflammation and angiogenesis, which lead to fibrosis that can cause loss of use of the membrane. A new study from China proposes that melatonin may break this cycle.

Read the abstract » | (added 2023-10-13)

Tags: Melatonin, Peritoneal Fibrosis, Glucose, GSDME, Pyroptosis

Magnesium Inhibits the Peritoneal Calcification of Late-stage EPS in Mice

Encapsulating peritoneal sclerosis (EPS) is a devastating and potentially lethal complication of PD. The reasons for EPS are not clear, but phosphate loading seems to contribute to the condition. This study successfully induced peritoneal calcification in mice—and found that administering magnesium into the peritoneum suppressed fibrosis and calcification.

Read the abstract » | (added 2023-10-13)

Tags: Encapsulating Peritoneal Sclerosis, Magnesium, Peritoneal Calcification, EPS