Journal Watch
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ISPD Position Paper: Teaching PD
The International Society for Peritoneal Dialysis adds a new 2025 Position Paper that builds on two prior works to help clinicians teach patients/care partners. Key areas include education, knowledge, skills, and attributes for PD nurse trainers; preparation for training; methods/interventions; post-training; and outcomes measures.
Read the abstract » | (added 2025-10-14)
Tags: ISPD, Teaching PD, Care Partners, Post Training, Outcome Measures
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First-in-human Trial of Sorbent-assisted Continuous Flow PD
One downside of peritoneal dialysis (PD) is the need to truck bags of sterile fluid to patients. A new sorbent-assisted PD (SAPD) device regenerates spent dialysate. SAPD may improve uremic solute clearance by maintaining a high concentration gradient and increasing the mass transfer area coefficient. It may help preserve peritoneal membranes longer by avoiding high glucose concentrations. And, fewer connections may mean less peritonitis. Short-term safety and performance of SAPD will be evaluated in a group of 12 stable adulte PD patients.
Read the abstract » | (added 2025-10-14)
Tags: First in human Trial, Continuous Flow Peritoneal Dialysis, Sorbent assisted Peritoneal Dialysis, Sapd, Peritonitis
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Challenges and Opportunities in Managing Individuals with Obesity on Peritoneal Dialysis
Some view obesity as a contraindication to PD, which limits treatment options for many patients. However, PD can be successfully utilized by people with obesity! Careful planning of the exit site can help.
Read the abstract » | (added 2025-09-15)
Tags: Obesity, Peritoneal Dialysis, Exit Site
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Amino acid and protein losses in adult patients receiving maintenance dialysis: a literature review
Patients on dialysis lose amino acids/protein on HD, hemodiafiltration (HDF). home HD, peritoneal dialysis (PD) and nocturnal HD (NHD). Protein losses were greater with HDF compared to HD. Patients on daily PD lose more amino acids/protein than those on HD.
Read the abstract » | (added 2025-09-15)
Tags: Amino Acids, Protein Loss, Dialysis
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Mechanism of AGE Damage to Peritoneal Membranes
Advanced glycation end-products (AGEs) are a well-known reason for peritoneal inflammation, though we didn’t know why. Researchers developed a way to study the Maillard reaction in collagen at near-physiological temperatures and found markedly increased permeability to small and medium-sized molecules as well as reduced proliferation of adherent mesothelial cells.
Read the abstract » | (added 2025-05-20)
Tags: Advanced Glycation End products, AGEs, Peritoneal Inflammation, Maillard Reaction
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Progress in PD Fluid
While glucose-based PD fluids are inexpensive, non-physiological PD fluid can, ironically, damage the peritoneum and cause devastating complications including peritoneal fibrosis and encapsulating peritoneal sclerosis (EPS). Neutral pH and solutions low in glucose degredation products (GDPs) help preserve peritoneal integrity and residual renal function, while using other osmotic agents such as icodextrin can improve ultrafiltration. Alternative buffers are also helpful.
Read the abstract » | (added 2025-03-13)
Tags: PD Fluid, Glucose Degredation Products, Icodextrin, Peritoneal Fibrosis, Encapsulating Peritoneal Sclerosis
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Do Ketoanalogue (KA) Supplements Preserve Residual Kidney Function in PD?
A 1-year, six center, randomized, double-blind trial investigated the impact of KA supplements on RKF in 153 CAPD patients vs. placebo. For patients with early PD initiation, the KA group had a significantly lower decline in RKF. No differences were found in RKF decline in those with late PD starts or in PD adequacy, peritoneal function, nutritional status, or quality of life scores between groups.
Read the abstract » | (added 2024-12-11)
Tags: KA Supplements, Residual Kidney Function, CAPD, Ketoanalogues
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Risk Factors for Cognitive Impairment in Peritoneal Dialysis
A retrospective analysis of 268 CAPD patients from January 2020 to September 2023. categorized participants into a cognitively impaired (CI; 58.2%) and a cognitively normal (CN) group. Logistic regression analysis identified male gender, older age, lower educational attainment, hypercholesterolemia, and elevated high-sensitivity C-reactive protein levels as independent risk factors for CI in CAPD patients (P < .05), while dialysis duration and residual renal function were protective against CI (P < .05).
Read the abstract » | (added 2024-08-16)
Tags: CAPD, Cognitive Impairment, Logistic Regression Analysis, Risk Factors
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Best Practices in Interventional Radiology for Peritoneal Dialysis
The Italian Society of Nephrology has endorsed a practical core curriculum for interventional nephrology in PD and has made it available on the Society website. The core curriculum addresses abdominal wall hernias, catheter placement with open surgical technique, video laparoscopy, cuff-shaving and more.
Read the abstract » | (added 2024-08-16)
Tags: Peritoneal Dialysis, Interventional Nephrology, Catheter Placement, Hernia
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The effect of urgent-start peritoneal dialysis and urgent-start hemodialysis on clinical outcomes in patients with chronic kidney disease: an updated systematic review and meta-analysis
Recently, urgent-start peritoneal dialysis (PD) has been suggested in place of urgent-start hemodialysis (HD) in cases of chronic kidney disease (CKD). However, the comparative effectiveness of these methods is still unclear. This study compared the outcomes of urgent-start PD and urgent-start HD in CKD patients.
Read the abstract » | (added 2024-03-15)
Tags: Dialysis related Complications, Hemodialysis, Kidney Disease, Mechanical Complications, Mortality, Peritoneal Dialysis, Renal Replacement Therapy