Journal Watch
Magnesium Inhibits the Peritoneal Calcification of Late-stage EPS in Mice
Encapsulating peritoneal sclerosis (EPS) is a devastating and potentially lethal complication of PD. The reasons for EPS are not clear, but phosphate loading seems to contribute to the condition. This study successfully induced peritoneal calcification in mice—and found that administering magnesium into the peritoneum suppressed fibrosis and calcification.
Read the abstract » | (added 2023-10-13)
Tags: Encapsulating Peritoneal Sclerosis, Magnesium, Peritoneal Calcification, EPS
Italians Improve on Daily Home HD
As in the U.S., the Italian Ministry of Health has home dialysis as a primary objective. In a 2-year study of seven people switched to six times per week daily home HD, significant improvements began to appear almost immediately. After 3-6 months, bone mineral balance and blood pressure were better, PTH levels and use of phosphate binders dropped, and the participants needed less rhEPO.
Read the abstract » | (added 2021-11-12)
Tags: Home Dialysis, Daily Home HD, RhEPO, Mineral Balance, Blood Pressure, PTH Levels
Home vs. In-center HD Outcomes from a Matched Cohort
After adjusting for BMI, smoking, race, and comorbidities, home HD came out ahead of in-center HD when 181 home HD patients were matched to 413 using in-center HD. With home HD, the risk of death was significantly less, and phosphate levels were significantly lower. There were no major differences in transplant rates, graft survival, hemoglobin, calcium, or PTH levels.
Read the abstract » | (added 2021-06-15)
Tags: Dialysis Modality; End stage Kidney Disease; Haemodialysis, Hemodialysis, Home Haemodialysis, Home Hemodialysis, Mortality
Yet Another Study Demonstrates the Superiority of Home HD over In-Center
A cohort registry study matched 181 home HD patients with 413 in-center HD patients in Australia and New Zealand by age, gender, and cause of ESKD. After adjusting for BMI, smoking, race, and comorbidities, home HD had almost half the death risk of in-center HD, as well as significantly lower phosphate levels. Both groups had similar rates of transplant and graft survival 6 months after a transplant.
Read the abstract » | (added 2021-01-12)
First European Patients Using Nocturnal Home HD with Low-flow Dialysate
A retrospective analysis looked at 21 patients using low-flow dialysate for nocturnal home HD and followed for a minimum of 12 months. Participants had a mean dialysis duration of 28 hours per week; most used alternate nights and 50-60 L of dialysate per session. Use of phosphate binders and blood pressure medications was significantly reduced, and no patient safety events were reported.
Read the abstract » | (added 2020-01-09)
Tags: Low flow Dialysate, Nocturnal Home HD, Phosphate Binders, Blood Pressure Medication
How longer HD treatments affect bone minerals
The ACTIVE study randomized 200 people to do 24+ hours of HD per week vs. standard (<18 hours per week) HD. Long HD treatments reduced serum phosphate levels, but did not change PTH or serum calcium. In a second analysis of the data, those who did longer HD needed fewer phosphate binders as well.
Read the abstract » | (added 2019-07-15)
Tags: HD Duration, Long Hd Treatment, Serum Phospate, Mineral Metabolism, Phosphate Binders
New Model Could Help Screen PD Patients for CeVD Risk
A new risk score could predict how likely new PD patients are to develop cerebrovascular disease down the road. The strongest predictors of CeVD were blood pressure, total cholesterol, and serum phosphate and sodium levels.
Read the abstract » | (added 2018-08-13)
Tags: Cerebrovascular Diseases, Mortality, Peritoneal Dialysis, Risk Prediction
A Randomized, Controlled Trial of Instant Messaging for PD Patients
Among 160 PD patients, the half assigned to instant messenger had significantly higher levels of satisfaction, serum albumin, and hemoglobin—and lower levels of serum phosphorus and calcium-phosphate product than controls.
Read the abstract » | (added 2018-05-11)
Nocturnal Home HD Boosts Patient Employment Compared to PD
A year-long study comparing 20 alternate-night nocturnal home hemodialysis patients to matched 81 CAPD patients in Hong Kong found 80% employment among the nocturnal HD patients (who were 5 years younger) and just 33.3% among PD patients. The nocturnal patients also used fewer phosphate binders. Read the abstract.
Read the abstract » | (added 2017-11-13)
Tags: Chinese, Nocturnal Hemodialysis, Employment Rate, Incident, Peritoneal Dialysis
Iron-based Binder Safe and Effective in PD
A study conducted with 84 PD patients compared sucroferric oxyhydroxide (n=56) to sevelamer (n=28). After a year, both groups had serum phosphate levels within the target range. The iron-based binder required fewer pills per day and resulted in fewer adverse events. Read the abstract.
Read the abstract » | (added 2017-11-13)
Tags: Chronic Kidney Disease, Hemodialysis, Peritoneal Dialysis; Phosphate Binder, Sevelamer Carbonate, Sucroferric Oxyhydroxide