Journal Watch
Risk Factors for Cognitive Impairment in Peritoneal Dialysis
A retrospective analysis of 268 CAPD patients from January 2020 to September 2023. categorized participants into a cognitively impaired (CI; 58.2%) and a cognitively normal (CN) group. Logistic regression analysis identified male gender, older age, lower educational attainment, hypercholesterolemia, and elevated high-sensitivity C-reactive protein levels as independent risk factors for CI in CAPD patients (P < .05), while dialysis duration and residual renal function were protective against CI (P < .05).
Read the abstract » | (added 2024-08-16)
Tags: CAPD, Cognitive Impairment, Logistic Regression Analysis, Risk Factors
PD vs. Home HD for Severe Infections
In a Finnish study of 536 patients using home dialysis, the risk of a severe infection (C-reactive protein of 100mg/L or higher) in year 1 of CAPD was 35%, APD was 25% and home HD was 11%. Over a 5-year period, compared to home HD, the hazard ratio of severe infection for APD was 2.2 and for CAPD, 2.8. PD peritonitis accounted for the difference.
Read the abstract » | (added 2023-07-17)
Tags: Home Dialysis, Severe Infection, C reactive Protein, CAPD, APD, HD, Home HD, PD Peritonitis
Roxadustat for Anemia in PD
The anemia drug was tested in 129 people on PD randomized to roxadustat or other ESAs for 24 weeks. The roxadustat group had a 96% response rate (vs. 92%), lower hepcidin levels and higher TIBC. Total cholesterol and LDL dropped more with roxadustat, independently of C-reactive protein. Mean average hemoglobin on roxadustat were 11.5 g/dL (vs. 11.2). There were some common adverse events.
Read the abstract » | (added 2021-07-12)
Tags: Prolyl Hydroxylase Inhibitor, Erythropoiesis, Iron Metabolism, Anemia
C-reactive Protein to Albumin Ratio (CAR) on PD Predicts Survival
An analysis of 758 PD patients observed for up to 12 years found that those whose CAR was lower were significantly more likely to survive than those whose CAR was higher.
Read the abstract » | (added 2020-08-11)
Tags: Serum C reactive Protein To Albumin Ratio, Serum C reactive Protein, PD, Peritoneal Dialysis
Protein Clearance Predicts Mortality on PD
Protein clearance on PD may be a marker of peritoneal inflammation. Among 711 PD patients followed for at least one year, each 10mL/day rise in protein clearance was linked with a 10.4% increase in the risk of all-cause mortality (p=0.008). Protein clearance was linked with serum albumin and C-reactive protein levels.
Read the abstract » | (added 2018-12-14)
PD After Loss of Residual Kidney Failure
Once residual kidney function is gone, it is vital to address fluid volume, finds a new study that followed 183 people. During the 10.5-36 months of follow up, 65% either switched to HD or died. Their inflammation rates (measured by C-reactive protein levels) were high, as were their extracellular water levels (measured by bioelectrical impedance analysis).
Read the abstract » | (added 2016-01-10)
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CRP levels and abdominal CT scans can find EPS early
A look back at CT scans and c-reactive protein levels from 30 people diagnosed with encapsulating peritoneal sclerosis has provided clues for early diagnosis. Higher than normal levels of c-reactive protein plus abnormal CT scan results found the rare complication early 78% to 87% of the time—making effective treatment more possible.
Read the abstract » | (added 2015-09-11)
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Men on PD fare worse with high serum uric acid levels
In a study of 985 people using PD in China followed for more than 2 years, men in the highest tertile for serum uric acid were at the highest risk of death. The results were adjusted for age; BMI; comorbidities; residual kidney function; total Kt/V; use of allopurinol, ACE-inhibitors and ARBs; Hgb, serum albumin, creatinine, calcium and phosphorus, triglycerides, LDL cholesterol, and high-sensitivity C-reactive protein.
Read the abstract » | (added 2014-09-05)
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Inflammation in PD? Look to the gums!
Researchers looked at gum disease in 68 people who were doing CAPD, and rated it as healthy, slight to moderate, and severe. Patients whose C-reactive protein levels (a marker of inflammation) were higher had worse gum disease and had been on PD longer. Those with heart disease and diabetes also had worse gum disease. The authors suggest that all people who use PD should have their gums checked.
Read the abstract » | (added 2014-06-05)
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High-sensitivity CRP levels predict technique and patient survival on PD
High C-reactive protein (CRP) levels suggest inflammation. Among 402 PD patients followed for 2 years, those with the lowest CRP levels were more likely to still be on PD and had better survival. Each 1 mg/L increase in CRP predicted a 1.4% higher risk of mortality.
Read the abstract » | (added 2014-04-09)
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