Low serum vitamin D levels, anemia, and inflammation on PD

When 62 people on PD were compared to 56 healthy volunteers, the PD group had significantly lower vitamin D levels—and significantly higher inflammatory markers (HS-CRP, IL-6, and TNF-α). The researchers concluded that low vitamin D levels contribute to anemia, oxidative stress, and microinflammation.

Read the abstract » | (added 2021-10-13)

Tags: PD, Vitamin D, Inflammatory Markers, Anemia, Oxidative Stress, Microinflammation

Roxadustat for Anemia in PD

The anemia drug was tested in 129 people on PD randomized to roxadustat or other ESAs for 24 weeks. The roxadustat group had a 96% response rate (vs. 92%), lower hepcidin levels and higher TIBC. Total cholesterol and LDL dropped more with roxadustat, independently of C-reactive protein. Mean average hemoglobin on roxadustat were 11.5 g/dL (vs. 11.2). There were some common adverse events.

Read the abstract » | (added 2021-07-12)

Tags: Prolyl Hydroxylase Inhibitor, Erythropoiesis, Iron Metabolism, Anemia