Journal Watch

  1. Nocturnal HD Protects Bones Better Than Standard HD

    Compared to 52 patients on conventional HD, 36 patients on nocturnal HD had better bone mineral density at the lumbar spine, femoral neck, and hip after one year.

    Read the abstract » | (added 06/08/2016)

    Tags: Hemodialysis

  2. Glucose in PD Solution Affects Non-Diabetic Patients, Too

    Among 640 PD patients from three countries studied for up to 6.4 years, serum glucose levels rose with age and with higher dialysate glucose. In 5.4% of the sample, the levels suggested undiagnosed diabetes.

    Read the abstract » | (added 06/08/2016)

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  3. More Inflammation With Standard HD Than With PD

    Inflammation can lead to heart damage and poor outcomes. Two 3-month prospective studies with 228 HD and 80 PD patients measured two markers of inflammation: CRP and IL-6. In HD patients, these levels were both higher and more variable than in PD.

    Read the abstract » | (added 06/08/2016)

    Tags: Hemodialysis

  4. Mechanisms of Peritoneal Membrane Fibrosis

    Glucose in PD solution activates a cell protein in mice that typically prevents fibrosis when it is not activated. This pathway leads to inflammation, growth of new blood vessels, and fibrosis—so finding a way to switch it off could lead to new drugs to help prevent these problems.

    Read the abstract » | (added 06/08/2016)

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  5. Low Blood Magnesium Levels Risky On PD

    Most magnesium in the body is not in the blood. And, very low blood levels (<1.8 mg/dL) were linked with higher rates of hospital stays and death among 10,692 people on PD. The greatest hospital risk was in patients who also had low (<3.5g/dL) serum albumin levels.

    Read the abstract » | (added 06/08/2016)

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  6. Preliminary Data for the VasQ™ Fistula Construction Tool

    A new Israeli device (available in three sizes) has been tested in 20 patients as a way to improve fistula flow and reduce hyperplasia at the anastomosis to reduce primary fistula failure. Primary patency was assessed at 1, 3, and 6 months, and there were no device-related adverse events. At the end of the study 14 of the 15 patients who required dialysis had a working fistula.

    Read the abstract » | (added 05/12/2016)

    Tags: Hemodialysis

  7. Kt/V Urea Should NOT Be Used as an Adequacy Measure for PD

    Since the National Cooperative Dialysis Study, PD adequacy attention has focused on urea clearance, rather than on the more important benefit of middle molecule clearance. In this opinion piece, Dr. Joanne Bargman asserts that the PD community “made a mistake” adopting urea kinetics to the peritoneal dialysis process,” an error that continues to this day despite the lack of evidence linking Kt/V to outcomes in PD patients.

    Read the abstract » | (added 05/12/2016)

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  8. Glycated Albumin More Accurate in PD than Glycated Hemoglobin

    Using hemoglobin A1c levels to assess glycemic control in people with diabetes using PD is risky, because anemia causes false negative results. In a 6-month study, 20 people with diabetes using HD were matched for age, sex, and post-meal glucose levels with people with diabetes using PD. In a multiple regression analysis, glycated albumin was the only independent predictor of plasma glucose levels.

    Read the abstract » | (added 05/12/2016)

    Tags: Hemodialysis

  9. Metaanalysis of Patient Education and Choice of PD

    An analysis of 15 studies (including one randomized controlled trial and 9 observational studies) found that patient-targeted education tripled the odds that patients would intend to use PD as a first treatment option.

    Read the abstract » | (added 05/12/2016)

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  10. Starting PD with Three Exchanges

    Are four PD exchanges magical? Or could new patients thrive with three exchanges per day, at least for a while? In a new study, 46 incident PD patients began treatment with three exchanges. During the 2 years of the study, 25% received a kidney transplant. Most were able to use three exchanges for a mean of 24 months before needing a fourth, and there was less loss of residual kidney function than in the predialysis period prior.

    Read the abstract » | (added 05/12/2016)

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