Journal Watch - Anemia
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Low serum vitamin D levels, anemia, and inflammation on PD
When 62 people on PD were compared to 56 healthy volunteers, the PD group had significantly lower vitamin D levels—and significantly higher inflammatory markers (HS-CRP, IL-6, and TNF-α). The researchers concluded that low vitamin D levels contribute to anemia, oxidative stress, and microinflammation.
Read the abstract » | (added 2021-10-13)
Tags: PD, Vitamin D, Inflammatory Markers, Anemia, Oxidative Stress, Microinflammation
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Roxadustat for Anemia in PD
The anemia drug was tested in 129 people on PD randomized to roxadustat or other ESAs for 24 weeks. The roxadustat group had a 96% response rate (vs. 92%), lower hepcidin levels and higher TIBC. Total cholesterol and LDL dropped more with roxadustat, independently of C-reactive protein. Mean average hemoglobin on roxadustat were 11.5 g/dL (vs. 11.2). There were some common adverse events.
Read the abstract » | (added 2021-07-12)
Tags: Prolyl Hydroxylase Inhibitor, Erythropoiesis, Iron Metabolism, Anemia