Glucose Degradation Product (GDP) Disrupts Peritoneal Membrane Function

Growth of new, immature blood vessels on the peritoneal membrane is linked with ultrafiltration failure. Exposure to the GDP methylgyoxal (MGO) up-regulated both vascular endothelial growth factor (VEGF) and suppressed platelet-derived growth factor (PDGF) in vitro, potentially disrupting the balance of angiogenesis.

Read the abstract » | (added 2020-03-16)

Tags: Peritoneal Membrane, Ultrafiltration Failure, Methylgyoxal, Angiogenesis