Portable, Wearable, and Implantable Artificial Kidneys

The need to continuously regenerate dialysate is a challenge for all portable, wearable, and implantable kidney replacement therapy options. Sorbent technology is one approach. New membrane materials can remove more uremic toxins than current ones. Combining these membranes with living kidney cells has potential as well.

Read the abstract » | (added 2023-06-14)

Tags: Dialysate, Portable, Wearable, Implantable Kidney, Kidney Replacement Therapy

24-hour Dietary Recall Less Accurate for Protein Intake Assessment in PD

Among 50 PD patients, use of protein nitrogen appearance (PNA) revealed levels of protein that ranged from 48.27-67.74 grams per day; median 55.75—while 24-hour dietary estimated the levels at 45.28-87.40; median 61.43 g/day. The authors suggest that proportionality bias may have influenced the results.

Read the abstract » | (added 2020-10-12)

Tags: Dialysis Initiation, Dialysate, Peritoneal Dialysis, PD

Impact of daily low-flow HD on potassium and lactate levels

In the NxStage FREEDOM study, 345 patients switched from standard in-center HD to daily, low-flow HD. Blood levels of potassium and lactate were analyzed during the last 3 months of standard HD and the first 3 months of daily HD. On daily HD, predialysis serum potassium decreased significantly at a dialysate potassium level of 1 mEq/L, with no change at 2 mEq/L. Predialysis serum bicarbonate level decreased significantly with dialysate lactate concentration of 40 mEq/L—but increased significanty at 45 mEq/L. Choosing the correct dialysate for the patient is important.

Read the abstract » | (added 2019-07-15)

Tags: Daily HD, Potassium, Bicarbonate, Dialysate

MXene Sorbents: A Step Toward a WAK

A sorbent tested for use in a wearable artificial kidney was able to adsorb urea with 99% efficiency in testing—twice the level removed with standard dialysate. The hemocompatible sorbent did not damage cells or reduce cell viability at the concentrations tested. A successful sorbent product will facilitate the design of a WAK. Read the abstract.

Read the abstract » | (added 2018-10-12)

Tags: Wearable Artificial Kidney, 2D Materials, Urea, MXene, Adsorption, Dialysate