And, Again: More HD Improves Quality of Life

Data from the Frequent Hemodialysis Network (FHN) trials found that those who were randomized to frequent or nocturnal HD reported outcomes that included better results on a “feeling thermometer,” better general health, and shorter recovery time than for standard in-center HD.

Read the abstract » | (added 2017-03-09)

Tags: Hemodialysis

Home HD: Cost-effective With Better Outcomes Than In-center

A review of the patient-centered and economic impacts of home HD that included studies between 2000 and 2016 found better quality of life, flexibility, employment potential, and survival vs. hospital HD. Minority and low-income patients still have less access than others, which compounds their already-poor health outcomes. The authors found that home HD is cost-effective and the use of this option should be increased.

Read the abstract » | (added 2017-03-09)

Tags: Hemodialysis

Peritonitis Predicts Long-term Cardiac Outcomes on PD

A large study (n=5,707) of PD patients from Brazil has found that just one bout of peritonitis boosts the risk of late cardiovascular death by 22%. Two bouts of peritonitis raised the risk by 78%, three by 181%, and four by 284%.

Read the abstract » | (added 2017-01-09)

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Early and Late Outcomes in Urgent-start PD

A single-center, matched-case control study compared 26 urgent start PD patients to 78 who started PD in the standard fashion. Urgent-start PD was linked with more catheter leaks and catheter migration. But, the rates of infection were similar, and urgent-start PD was safe.

Read the abstract » | (added 2017-01-09)

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PD Patient Education in Australia

Clinical PD outcomes in Australia were as much as 10-fold different from one site to another. An effort to standardize PD teaching has begun to improve PD outcomes. Of the 54 PD clinics, 70% completed an online survey about their PD teaching practices—which varied widely in the number of hours and presence of competency assessments.

Read the abstract » | (added 2017-01-09)

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NxStage Outcomes in France and Belgium

Among 62 patients from 31 centers in France and Belgium, albumin and bicarbonate levels improved significantly, and technique survival was 75% at one year (most who stopped received transplants). Despite the low volume of dialysate, the rsearchers concluded that dialysis adequacy was acceptable.

Read the abstract » | (added 2016-12-09)

Tags: Hemodialysis

Encapsulating Peritoneal Sclerosis (EPS) Incidence and Outcomes

A new Scottish registry study found that 2.8% of PD patients between 2000 and 2007 (n=1,238) developed EPS. The rate rose from 1.1% by year 1 to 3.4% at year 3, 8.8% at year 4, 9.4% at year 5, and 22.2% by year 7. The authors note that “continuing PD beyond 3 years results in an exponential rise in the risk of developing EPS and deciding whether this risk is acceptable should be made on an individual patient basis.”

Read the abstract » | (added 2016-08-09)

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More Inflammation With Standard HD Than With PD

Inflammation can lead to heart damage and poor outcomes. Two 3-month prospective studies with 228 HD and 80 PD patients measured two markers of inflammation: CRP and IL-6. In HD patients, these levels were both higher and more variable than in PD.

Read the abstract » | (added 2016-06-08)

Tags: Hemodialysis

Kt/V Urea Should NOT Be Used as an Adequacy Measure for PD

Since the National Cooperative Dialysis Study, PD adequacy attention has focused on urea clearance, rather than on the more important benefit of middle molecule clearance. In this opinion piece, Dr. Joanne Bargman asserts that the PD community “made a mistake” adopting urea kinetics to the peritoneal dialysis process,” an error that continues to this day despite the lack of evidence linking Kt/V to outcomes in PD patients.

Read the abstract » | (added 2016-05-12)

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Urea Alone is Not a Good Index of Dialysis Dose

All-cause mortality in the HEMO study was not significantly related to removal of small solutes in short, intermittent, standard HD. “Failure to achieve greater reductions in solute levels may explain the failure of high Kt/V urea treatment to improve outcomes,” the authors note. (Yet another reanalysis of the HEMO study data has confirmed the obvious…)

Read the abstract » | (added 2016-04-12)

Tags: Hemodialysis