Journal Watch - Peritonitis
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Systematic Review of Culture-directed Antibiotics for Peritonitis
A review of 28 articles identified 18 antibiotics used for peritonitis, of which 9 (cefotaxime, ceftriaxone, daptomycin, ofloxacin, and teicoplanin in glucose-based solutions, tobramycin in Extraneal solution only and fosfomycin in Extraneal, Nutrineal, Physioneal 1.36% and 2.27% glucose solutions ) can be dosed interaperitoneally. Stability has not yet been demonstrated for all of these.
Read the abstract » | (added 2023-08-16)
Tags: Peritonitis, Antibiotics, Culture directed Antibiotics, Peritoneal Dialysis Solutions
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Factors Linked with Time to First Peritonitis on PD
In a 5-year, 57 clinic, prospective randomized controlled trial in Europe, 33% of 671 participants had a bout of peritonitis. The factors independently linked with time to first peritonitis included older age, higher number of PD bags, low serum albumin, and higher body weight.
Read the abstract » | (added 2023-04-19)
Tags: Peritonitis, Age, PD Bags, Serum Albumin, Body Weight
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Blood Vessel Damage Key to Encapsulating Peritoneal Sclerosis (EPS)
A study evaluated tissue samples from 174 PD patients with EDS and had used either conventional or neutral pH, low glucose degradation product PD solution. The conventional PD solution group had less angiogenesis but more severe blood vessel damage (P <0.001) and a higher rate of EPS relapse. Blood vessel damage was milder in the neutral pH group.
Read the abstract » | (added 2020-06-10)
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Glucose and Peritonitis
A prospective, longitudinal cohort study followed 105 PD patients for up to 5 years (mean of 23 months). Higher glucose exposure significantly predicted peritonitis, and patients with more residual kidney function also had a significantly longer time to first bout of peritonitis. Read the abstract. The authors suggest using the lowest concentration of glucose possible.
Read the abstract » | (added 2020-03-16)
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Comorbidities—but not Peritonitis—drove Mortality on PD
Among 242 Turkish PD patients followed for up to 9 years, age over 65, diabetes, cancer, and heart failure were independent risk factors for death, but surprisingly peritonitis was not.
Read the abstract » | (added 2020-02-19)
Tags: Peritoneal Dialysis, Mortality, Patient Survival, Peritonitis, Technique Survival
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Diabetes and the Risk of Peritonitis on PD
In contrast to earlier reports, a single-center study of PD patients between 1980 and 2012 (by era: 1980-’93, 1994-’04, 2005-12) found that while PD-associated peritonitis was higher among patients with diabetes in the earlier two eras, there were no differences in recent years.
Read the abstract » | (added 2020-01-09)
Tags: PD, Peritonitis, Diabetes
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Antibiotics Before Colonoscopy May Reduce Peritonitis Risk in PD Patients
In a retrospective study of 236 CAPD patients who had colonoscopies, 9 developed peritonitis within a week of the procedure. No patient who received prophylactic antibiotics developed peritonitis. Randomized controlled trials are recommended.
Read the abstract » | (added 2019-11-16)
Tags: CAPD, Colonoscopy, Peritonitis, Prophylactic Antibiotics, Polypectomy, Endoscopic Mucosal Resection
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Proton Pump Inhibitors Increase Peritonitis Risk in PD
In a single-center, 36-month retrospective look at 230 Japanese PD patients, those who took PPIs were 72% more likely to develop peritonitis than those who did not.
Read the abstract » | (added 2019-11-16)
Tags: PD, PPIs, Peritonitis, Proton Pump Inhibitors
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PD Fluid Overload Linked with Peritonitis from Gut Pathogens
PD patients with extra fluid in their bodies are at a significantly higher risk for peritonitis due to gut bacteria, finds a study of 138 patients. Patients in the highest third for intra-and extracellular water were at the highest risk.
Read the abstract » | (added 2019-05-15)
Tags: Body Composition, Overhydration, Peritoneal Dialysis, Peritonitis
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Cognitive Impairment Predicts PD Peritonitis
A prospective cohort study assigned 458 PD patients to a cognitively impaired (CI) or non-CI group based on results of mental state testing. The groups were not otherwise significantly different. Over 31.4 (median) months, 94 patients had first-time peritonitis, and short-term memory losses were independently linked with a higher risk.
Read the abstract » | (added 2019-04-11)