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  • Mineral Bone Disease (MBD) and Survival on PD

    A P-DOPPS study analyzed MBD data from more than 12,000 patients from eight countries. The results revealed a U-shaped curve for the relationship between PTH and mortality, with the lowest risk at PTH levels of 300-599 pg/mL. Serum calcium levels higher than 9.6 mg/dL were associated with a 20% increase in mortality as well. Major country variations in MBD treatment were identified.

    Read the abstract » | (added 2024-04-12)

    Tags: Mineral Bone Disease, MBD, PTH, Mortality, Serum Calcium Levels, PD

  • Meta-analysis of Urgent Start vs. Conventional Start PD

    Analysis of data from 27 studies found comparable post-procedure infections, peritonitis, and exit site infections, technique survival, and transfer to HD for urgent and conventional start PD. Urgent start PD had a signficantly higher risk of mechanical complications such as leaks, and significantly higher mortality rates.

    Read the abstract » | (added 2024-03-15)

    Tags: Chronic Kidney Disease, Meta analysis, Peritoneal Dialysis

  • Urgent-start PD vs. Urgent-start HD: Meta-analysis

    Analysis of data from nine studies looking at all-cause mortality found a rate of 0.173 for urgent-start PD vs. .214 for urgent-start HD. Those who started PD urgently had lower risks of infection-related death, bacteremia, and other complications, though rates of cardiovascular and cancer mortality were similar.

    Read the abstract » | (added 2024-01-17)

    Tags: All cause Mortality, Urgent start PD, Urgent start HD, Infection related Death, Bacteremia

  • Surprising Impact of First Dialysis Modality on Survival in Patients with Diabetes

    A retrospective cohort study of 739 patients from 2010 to 2018 (inclusive) used propensity score matching to compare mortality between standard HD and PD in China, matching 125 PD patients with HD patients. No significant differences were found—except in those with diabetes, who had significantly better survival with PD.

    Read the abstract » | (added 2023-11-15)

    Tags: Modality, Survival, Diabetes, Propensity Score Matching

  • Rate of Residual Kidney Function Decline and Mortality in PD

    When 497 PD patients were divided into two groups based on RRF decline value, those in the fast-decline group had significantly higher rates of all-cause and cardiovascular mortality. In fact, each 0.1mL/min/1.73m2 per month drop in RRF in the first year of PD predicted a 19% higher risk of all-cause mortality and a 20% higher risk of cardiovascular mortality.

    Read the abstract » | (added 2023-11-15)

    Tags: Rate Of Residual Kidney Function Decline, All cause Mortality, Cardiovascular Mortality

  • Longer Survival with Extended Home HD

    A study in Turkey compared 348 patients doing extended home HD (418 minutes) matched with 1,047 doing standard in-center HD (242 minutes) and followed both groups for about 55 months. The extended home HD patients had an all-cause mortality rate of 3.76 per 100 patient years—vs. 6.27 for the in-center HD patients; a significant 40% reduction.

    Read the abstract » | (added 2023-10-13)

    Tags: Extended Home HD, Survival, All cause Mortality Rate

  • Incremental PD and Quality of Life

    In a 4-year study (2015-2019) of adults starting PD and followed for one year, those who used incremental PD had better KDQOL physical composite, burden of kidney disease, and effects of kidney disease scores, as well as less hospitalization and lower mortality rates (non-significant).

    Read the abstract » | (added 2023-09-13)

    Tags: Incremental PD, KDQOL, Mortality Rate, Quality Of Life

  • Systemic Immune-Inflammation Index (SII) and Mortality on PD

    Among 1,419 PD patients from 2007 to 2019, SII was calculated as platelet count x neutrophil count/lymphocyte count. During a median 42 month follow up, 321 patients died, 171 of cardiovascular disease. Each 1 standard deviation increase in the SII was associated with a 20.2% rise in all-cause mortality and 28% in cardiovascular-specific mortality.

    Read the abstract » | (added 2023-09-13)

    Tags: PD, Mortality, Systemic Immune inflammation Index

  • Incremental PD and Patient Outcomes: Registry Data

    Between 2007 and 2017, incremental PD use increased by 2.7% in the ANZDATA database. Most (67%) used the approach for one year or less. After controlling for patient and center variables, starting PD with incremental treatments reduced peritonitis risk and transfers to in-center HD, with no increase in mortality.

    Read the abstract » | (added 2023-09-13)

    Tags: Incremental PD, Incremental Treatments, Peritonitis, Mortality Rate

  • Early Survival Advantage for Incremental PD

    From 2008 to 2017, 1,315 patients from one hospital who started PD were enrolled in a study that propensity matched them 1 (incremental; n=285):2 (full dose; n=502) for age, sex, residual kidney function and urine volume, hemoglobin, serum albumin, and other variables. For the first 6 years, intermittent PD had significantly better survival than full dose PD, with a 39% lower risk of all-cause mortality and 41% less cardiovascular mortality. This advantage disappeared with longer time on PD.

    Read the abstract » | (added 2023-09-13)

    Tags: Intermittent PD, Full Dose PD, Mortality