Journal Watch

  • Systemic Immune-Inflammation Index (SII) and Mortality on PD

    Among 1,419 PD patients from 2007 to 2019, SII was calculated as platelet count x neutrophil count/lymphocyte count. During a median 42 month follow up, 321 patients died, 171 of cardiovascular disease. Each 1 standard deviation increase in the SII was associated with a 20.2% rise in all-cause mortality and 28% in cardiovascular-specific mortality.

    Read the abstract » | (added 2023-09-13)

    Tags: PD, Mortality, Systemic Immune inflammation Index

  • Outcomes with PD to HHD Compared to Direct HHD

    Analysis of data from all patients who started PD or HHD in the first 90 days of kidney replacement therapy in Canada matched PD+HHD patients (n=163) 1:1 to incident HHD patients (n=711). Interestingly, while hospitalization risk was similar, clinical outcomes were better in the PD+HHD group.

    Read the abstract » | (added 2023-09-13)

    Tags: PD, HHD, Kidney Replacement Therapy, Clinical Outcomes

  • ISPD Proposes to Remove PD Toxin Clearance Targets

    New ISPD Guidelines suggest that the focus of PD should be patient well-being—not lab values. This change would allow more people to do PD, and focusing on relieving uremic symptoms could help determine which solutes really do matter to quality of life.

    Read the abstract » | (added 2023-08-16)

    Tags: PD, Patient Well being, Lab Values, Uremic Symptoms, Quality Of Life

  • Skilled Nursing Facility “Home” Dialysis Improves Rehabilitation

    Rehab therapies take time—and so does going off-site for in-center dialysis. Offering more frequent dialysis (MFD) at SNFs saves time. Does it improve PT participation? Yes, finds a new retrospective EMR review study. Compared to 562 in-center HD rehab patients, 92 people who received MFD in their SNF had higher PT participation rates (equivalent to almost 13,000 non-ESRD rehab patients), even though they had significantly more comorbidities.

    Read the abstract » | (added 2023-08-16)

    Tags: Rehabilitation Therapies, Skilled Nursing Facility, MFD, SNF, PT Participation, Comorbidities

  • Systematic Review of Culture-directed Antibiotics for Peritonitis

    A review of 28 articles identified 18 antibiotics used for peritonitis, of which 9 (cefotaxime, ceftriaxone, daptomycin, ofloxacin, and teicoplanin in glucose-based solutions, tobramycin in Extraneal solution only and fosfomycin in Extraneal, Nutrineal, Physioneal 1.36% and 2.27% glucose solutions ) can be dosed interaperitoneally. Stability has not yet been demonstrated for all of these.

    Read the abstract » | (added 2023-08-16)

    Tags: Peritonitis, Antibiotics, Culture directed Antibiotics, Peritoneal Dialysis Solutions

  • Disparities in Access to PD

    Per logistic regression of USRDS data from 2009 to 2019, the incident PD population more than doubled, with increases in PD use by seniors. There was a 5% increase in PD use by Hispanic people, but no difference in other races. Urban PD use also increased by 5%, and 7% for those in socioeconomically disadvantaged areas.

    Read the abstract » | (added 2023-08-16)

    Tags: Incident PD, PD Access, Disparity, PD Demographics

  • 2023 AJKD Core Curriculum in Nephrology

    Acute PD, more use of home treatments, and better peritoneal solute transfer models are part of the content of the new Core, which emphasizes the latest data for prevention and management of infectious and noninfectious complications of PD.

    Read the abstract » | (added 2023-08-16)

    Tags: Acute PD, Core Curriculum, Complications Of PD, Home Dialysis

  • How Glucose Causes Peritoneal Fibrosis

    Constant glucose exposure from PD dialysate often causes fibrosis that can make further PD impossible. High glucose causes chronic inflammation, interferes with lipid metabolism, and leads to angiogenesis and fibrosis. RAAS activation contributes to this process as well. There may be benefit to looking at the upstream pathways to see if there are ways to block fibrosis.

    Read the abstract » | (added 2023-08-16)

    Tags: High Glucose, PD Dialysate, Fibrosis

  • Meta-analysis of Quality of Life by ESRD Treatment Modality

    Analysis of 111 papers with more than 50,000 patients compared transplant, PD, home HD, and in-center HD for health-related quality of life outcomes. The rankings? Transplant, PD, home HD, in-center HD.

    Read the abstract » | (added 2023-08-16)

    Tags: Quality Of Life, ESRD, Treatment Modality

  • GI Outcomes in PD Trials

    A meta-analysis of 61 trials looking at patient-reported GI outcomes of PD mainly found nausea (43% of trials), diarrhea (43%), constipation (34%), abdominal pain (31%) and PD peritonitis (40%). But, only 19% of the available trials reported GI outcomes at all.

    Read the abstract » | (added 2023-07-17)

    Tags: GI Outcomes, PD, Nausea, Diarrhea, Constipation, Abdominal Pain, Peritonitis